Research and Studies

Emerging yet inconclusive case series regarding the role of omega-3 and vitamin E supplementation in children

A case series published in the July/August 2009 journal Alternative Therapies in Health and Medicine describes the benefits noted in 97% of participants while taking a nutritional combination comprised of omega-3 and vitamin E.

The Oxford-Durham Schools Trials

Initial Trial results summary:
The most comprehensive and thorough trial yet of how omega-3 may be applied in the classroom. This trial was run by the British Government through its Durham Education Authority. During the course of 2002, more than 100 children at 12 different schools were daily given either active or placebo capsules in a double-blind, randomized format. More than 12,000 assessments were undertaken in the course of the year. The first results were published in the American Journal Pediatrics and showed very significant improvements for active treatment versus placebo in reading, spelling, and behavior over 3 months of treatment in parallel groups. After the crossover, similar changes were seen in the placebo-active group, whereas children continuing with active treatment maintained or improved their progress.
“The response has been very encouraging. In very broad terms, we saw that up to 40% of children in the trial showed dramatic improvements.  In some individual cases, we saw reading age gains of between 18 months and 4 years, and attention gains of as much as 400%.”
—Dr. Madeleine Portwood, Senior Educational Psychologist
General References Regarding Omega-3 and Vitamin E
(not unique to the speak product):
Schuchardt JP, Huss M, Stauss-Grabo M and Hahn A. Significance of long-chain PUFA for the development and behavior of children. Eur J Pediatr 169: 149-164, 2010.

Belanger SA et al. Omega-3 fatty acid treatment of children with attention-deficit hyperactivity disorder: A randomized, double-blind, placebo-controlled study. Paediatr child health 14(2):89—98,2009.

Appleton KM, Rogers PJ and Ness AR. Is there a role for n-3 long-chain PUFA in the regulation of mood and behavior? A review of the evidence to date from epidemiological studies, clinical studies and intervention trials. Nutr Res Rev 21:13-41, 2008.

Hibbeln J et al. Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study. Lancet 369: 578-585, 2007.

Amminger GP et al. Omega-3 FA supplementation in children with Autism: a double-blind randomized placebo-controlled pilot study.  Biol Psychiatry 61:551-553, 2007.

Reis LC and Hibbeln JR. Cultural symbolism of fish and the psychotropic properties of omega-3 fatty acids. Prostaglandins Leukot Essent Fatty Acids  75:227-236, 2006.

Hart SL et al. Brief report: newborn behavior differs with DHA levels in breast milk. J Ped Psy  31(2):221-226, 2006.

Richardson AJ. Omega-3 fatty acids in ADHD and related neurodevelopmental disorders. Intern Rev Psych 18(2):155-172, 2006.
Stordy J. Dark adaptation, motor skills, docosahexaenoic acid and dyslexia. Am J Clin Nutr  71, 323S-326S, 2000.

Hart SL, et al. Brief report: newborn behavior differs with DHA levels in breast milk. J Ped Psy 31(2):221-226, 2006.
Bendich A and Machlin LJ.  Safety of oral intake of vitamin E. Am J Clin Nutr 48:612-9, 1988.

Brigelius-Flohe  R and Traber MG. Vitamin E: function and metabolism. FASEB J  13:1145-1155, 1999.

Traber MG and Packer L.  Vitamin E: beyond antioxidant function.  Am J Clin Nutr 62 (supp):1501S-9S. 1995.

Sokol RJ.  Vitamin E deficiency and neurologic disease.  Ann Rev Nutr :351-73, 1988.
Booth SL et al. Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status. Am J Clin Nutr 80:143-8, 2004.

Suttie, et al. Vitamin K deficiency from dietary vitamin K restriction in humans. Am J Clin Nutr 47:475-80, 1988.
Al-Gadani et al. Metabolic biomarkers related to oxidative stress and antioxidant status. Clin BioChem 42: 1032-1040 (2009).
Meguid, N, et al. Role of polyunsaturated fatty acids in the management of Egyptian children. Clin BioChem 41: 1044-1048 (2008).

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